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Dr. Casanova was appointed professor at Rockefeller University in 2008 and named HHMI investigator in 2014. Over the last 25 years, his laboratory discovered the first monogenic inborn errors of immunity, rare and common, which predispose otherwise healthy individuals to a single infectious disease, including a variety of viral, bacterial, and fungal infections. In response to the SARS-CoV2 Global Pandemic, Dr Casanova cofounded the COVID Human Genetic Effort with Helen Su at the NIAID. He discovered monogenic inborn errors of type I interferon immunity underlying severe forms of COVID-19 in previously healthy individuals. This led to his discovery that pre-existing autoantibodies to type I interferons account for at least 10% of severe cases.