Biophotonics and Bioimaging Seminar Series: Aaron Streets PhD Wednesday, November 15, 2017, 4:10 – 5pm
Biophotonics and Bioimaging Seminar Series: Aaron Streets PhD
Room:1005
Location of Event:UC Davis Campus
Cost:Free
Event Type:Free Events, Lectures and Seminars
Presented by:Biophotonics and Bioimaging Designated Emphasis

Imaging and Sequencing Single Cells

Quantitative cellular imaging with coherent Raman microscopy reveals morphological characteristics and chemical composition at the single-cell level.Meanwhile recent advances in high-throughput sequencing have enabled whole-transcriptome profiling of gene expression in single cells. Both measurements can uncover heterogeneity in cellular populations that would otherwise be obscured in ensemble measurement. Furthermore both imaging and gene expression profiling can be used to quantify cell state during differentiation. However, in order to infer the relationship between gene expression and morphological phenotypes, it is necessary to image and sequence the same single cell. We use a microfluidic platform to couple imaging and RNA sequencing of single cells and present recent developments on how to analyze large, multimodal, single-cell datasets.

Dr. Streets is an Assistant Professor of Bioengineering at UC Berkeley. Visit his lab website for more information: streetslab.berkeley.edu .

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