"Imaging as a Tool for Evaluating Neuropathology and Therapeutic Responses in a Preclinical Model of Toxicant-Induced Status Epilepticus" Thursday, April 12, 2018, 4:10 – 5pm
"Imaging as a Tool for Evaluating Neuropathology and Therapeutic Responses in a Preclinical Model of Toxicant-Induced Status Epilepticus"
Room:1005 (auditorium)
Location of Event:UC Davis Campus
Cost:Free
Event Type:Free Events, Lectures and Seminars
Presented by:Pam Lein
Sponsored by:Department of Biomedical Engineering

Imaging as a Tool for Evaluating Neuropathology and Therapeutic Responses in a Preclinical Model of Toxicant-Induced Status Epilepticus

There is a pressing public health need to identify improved medical countermeasures for treating acute intoxication with seizure-inducing chemical threat agents. The UC Davis CounterACT Center of Excellence focuses on two important credible threat agents identified by the Department of Homeland Security: the cage convulsant tetramethylenedisulfotetramine (TETS) and the organophosphate (OP) diisopropylfluorophosphate (DFP). Both can trigger prolonged, life threatening seizures known as status epilepticus (SE). Current medical countermeasures (atropine, 2-PAM and high dose diazepam or midazolam) can reduce mortality in exposed individuals, but they do so with significant side effects and are maximally effective only if administered within minutes of exposure. Survivors face significant, long-term morbidity including memory loss, affective disorders and recurrent seizures. This presentation will focus on the Center’s research efforts to develop quantitative imaging approaches for longitudinal monitoring of neuropathology and therapeutic efficacy in preclinical models of acute intoxication with TETS or DFP. These include the application of high content imaging for unbiased image acquisition and analyses of histological and immunohistochemical endpoints, ex vivo computed tomography imaging of mineralization in the brain, and longitudinal in vivo imaging with magnetic resonance imaging (MRI) and positron emission tomography (PET) of neuropathology and neuroinflammation.

Biomedical Engineering Departmental Seminar Series: Pam Lein, Professor, Department of Molecular Biosciences, School of Veterinary Medicine, UC Davis.

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